张江虹

发布时间：2022-09-30浏览次数：2875



个人简历

张江虹，医学博士，研究员，硕士研究生导师。主要从事肿瘤微环境介导辐射抵抗机制的研究，先后在英国牛津大学、英国贝尔法斯特女王大学作访问学者，主持国家自然科学基金、教育部、上海市科委等多项课题，发表本领域高水平论文多篇。


主持科研项目

  1. 张江虹，乏氧肺癌细胞外泌体蛋白ANGPTL4通过免疫调节辐射敏感性的机制研究，国家自然科学基金面上项目（2022-2025，12175044），直接经费61万。

  2. 张江虹，乏氧诱导的外泌体在肿瘤侵袭转移、血管生成和辐射抵抗中的作用及其机制研究，国家自然科学基金面上项目（2017-2020，81672985），直接经费53万。

  3. 张江虹，硫化氢在肝癌细胞乏氧辐射耐受中的作用机制研究，国家自然科学基金青年项目（2013-2015，31200631），23万。

  4. 张江虹，硫化氢在乏氧肝癌细胞辐射耐受中的作用和机制研究，上海市自然基金（2010-2012，09ZR1403600），10万。

  5. 张江虹，气体信号分子硫化氢在乏氧肝癌细胞辐射耐受中的作用和机制研究，国家教育部高校博士点基金（2010-2012，20090071120096），3.6万。

  6. 张江虹，硫化氢在乏氧引起的肿瘤细胞辐射耐受中的作用和机制研究，复旦大学青年科学基金（2008-2010，08FQ25），4万。


发表期刊论文

  1. Yuhong Zhang, Xinglong Liu, Liang Zeng, Xinrui Zhao, Qianping Chen, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment. British J. Cancer. DOI: 10.1038/s41416-022-01956-7, 2022.

  2. Qianping Chen#, Wang Zheng#, Jian Guan#, Hongxia Liu, Yao Dan, Lin Zhu, Yimeng Song, Yuchuan Zhou1, Xinrui Zhao, Yuhong Zhang, Yang Bai1, Yan Pan1*, Jianghong Zhang*, Chunlin Shao*. SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. Cell Death and Differentiation.https://doi.org/10.1038/s41418-022-01051-7.

  3. Wang Zheng†, Qianping Chen†, Hongxia Liu, Liang Zeng, Yuchuan Zhou, Xinglong Liu, Yang Bai, Jianghong Zhang*, Yan Pan*, Chunlin Shao*. SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes. Autophagy, doi: 10.1080/15548627.2022.2105562, 2022. (IF 13.4)

  4. Xinrui Zhao#, Songling Hu#, Liang Zeng, Xinglong Liu, Yimeng Song, Yuhong Zhang, Qianping Chen, Yang Bai, Jianghong Zhang, Haowen Zhang*, Yan Pan1*, Chunlin Shao*. Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated Tcell activation. iScience, 25, 104690, 2022. (IF 5.5).

  5. Yuchuan Zhou, Hongxia Liu, Wang Zheng, Qianping Chen, Songling Hu, Yan Pan, Yang Bai, Jianghong Zhang* and Chunlin Shao*. MMP14 contributes to HDAC inhibition-induced radiosensitization of glioblastoma. Int. J. Mol. Sci., 22(19): 10403, 2021.

  6. Yimeng Song#, Songling Hu#, Junling Zhang, Lin Zhu, Xinrui Zhao, Qianping Chen, Jianghong Zhang, Yang Bai, Yan Pan*, Chunlin Shao*. Fractionated irradiation of right thorax induces abscopal damage on bone marrow cells via TNF-α and SAA. Int. J. Mol. Sci., 22(18): 9964, 2021.

  7. Qianping Chen#, Wang Zheng#, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang*, Jian Guan*, Chunlin Shao*. LACTB2 Renders Radioresistance by Activating PINK1/Parkin-dependent Mitophagy in Nasopharyngeal Carcinoma Cells. Cancer Letters. 518: 127–139, 2021.

  8. Wang Zheng#, Qianping Chen#, Hongxia Liu, Songling Hu, Yuchuan Zhou, Yang Bai, Jianghong Zhang, Yan Pan and Chunlin Shao*. CD81 enhances radioresistance of glioblastoma by promoting nuclear translocation of Rad51. Cancers, 13:1998, 2021.

  9. Jianghong Zhang, Yuhong Zhang, Fang Mo, Gaurang Patel, Karl T Butterworth, Chunlin Shao*, Kevin Prise*. The roles of HIF-1α in radiosensitivity and radiation induced bystander effects under hypoxia. Frontiers in Cell and Developmental Biology, 9: 637454, 2020. DOI: 10.3389/fcell.2021.637454, 2021.

  10. Songling Hu#, Lin Zhu#, Yimeng Song#, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang*, Chunlin Shao*.Radiation-induced abscopal reproductive effect is driven by Rac1 nuclear translocation in Sertoli cells. Theranostics. 11(12): 5742-5758, 2021.

  11. Hongxia Liu, Wang Zheng, Qianping Chen, Yuchuan Zhou, Yan Pan, Jianghong Zhang, Yang Bai and Chunlin Shao*. LncRNA CASC19 Contributes to Radioresistance of Nasopharyngeal Carcinoma by Promoting Autophagy via AMPK-mTOR Pathway. Int. J. Mol. Sci. 22(3), 1407, 2021.

  12. Xiaofei Chu, Wang Zheng, Juan Wang, Jianghong Zhang, Yan Pan and Chunlin Shao. CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation. Biochemical and Biophysical Research Communications. 531: 328-334, 2020.

  13. Fei Chen#, Yushuo Zhang#, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang*, Chunlin Shao1*. TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation. Cell Death & Disease. 11: 501, 2020..

  14. Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. Exosomes from irradiated lung cancer cells carrying ALDOA and ALDH3A1 enhance migration and invasion of recipients by accelerating glycolysis. Molecular and Cellular Biochemistry, 469:77–87, 2020.

  15. Fang Mo, Yanwu Xu, Junling Zhang, Lin Zhu, Chen Wang, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Effects of hypoxia and radiation-induced exosomes on migration of lung cancer cells and angiogenesis of umbilical vein endothelial cells. Radiat. Res., 194: 71–80, 2020.

  16. Wang Zheng#, Qianping Chen#, Chen Wang, Xiaofei Chu, Dan Yao, Lin Zhu, Yan Pan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Inhibition of Cathepsin D (CTSD) enhances radiosensitivity in glioblastoma cells through attenuated autophagy. Molecular Carcinogenesis, 59:651–660. 2020.

  17. Qianping Chen#, Wang Zheng#, Lin Zhu, Dan Yao, JunLing Zhang ,Chen Wang, Fang Mo,Yimeng Song, Hongxia Liu, Songling Hu, Xiaofei Chu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. ANXA6 contributes to radioresistance by regulating cell autophagy and migration in nasopharyngeal carcinoma. Frontiers in Cell and Developmental Biology, 8:232, 2020.

  18. Fei Guo, Dexiao Yuan, Junling Zhang, Hang Zhang, Chen Wang, Lin Zhu, Jianghong Zhang, Yan Pan* and Chunlin Shao*. Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State. Frontiers in Cell and Developmental Biology, 2019 Oct 15; 7: 238. doi: 10.3389/fcell.2019.00238. eCollection 2019.

  19. Junling Zhang#, Dan Yao#, Yimeng Song, Yan Pan, Lin Zhu, Yang Bai, Yanwu Xu, Jianghong Zhang*, Chunlin Shao*. Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility. Scientific Reports, 9:15221, 2019.

  20. Junling Zhang#, Dan Yao#, Jianghong Zhang, Yimeng Song, Fang Mo, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao*. TGF-β mediates thoracic radiation-induced abscopal effects of testis injury in rat. Biochemical and Biophysical Research Communications. 514(3): 678-683, 2019.

  21. Xiangdong Wang, Wenzhi Tu, Chen Dong, Jiamei Fu, Juan Wang, Chunlin Shao*, Jianghong Zhang*. Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells.Int. J. Radiat. Biol.95(8): 1051-1057, 2019.

  22. Chen Wang, Wang Zheng, Dan Yao, Qianping Chen, Lin Zhu, Junling Zhang, Yan Pan, Jianghong Zhang, Chunlin Shao*. Upregulation of DNA metabolism-related genes contributes to radioresistance of glioblastoma. Human Gene Therapy Clinical Development. 30(2): 74-87, 2019.

  23. Chen X, Wang P, Guo F, Wang X, Wang J, Xu J, Yuan D, Zhang J*, Shao C*. Autophagy enhanced the radioresistance of non-small cell lung cancer by regulating ROS level under hypoxia condition. Int. J. Radiat. Biol. 93(8): 764-770, 2017.

  24. Yuexia Xie, Shuang Ye, Jianghong Zhang, Mingyuan He, Chen Dong, Wenzhi Tu, Peifeng Liu, Chunlin Shao*. Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells.Scientific Reports,6:38832, 2016.

  25. Yuan D, Xu J, Wang J, Pan Y, Fu J, Bai Y, Zhang J*, Shao C*. Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5. Oncotarget. 7(22): 32707-22, 2016.

  26. Pan, Y., Zhou, C., Yuan, D., Zhang, J. and Shao C*. Radiation Promotes Hepatocarcinoma Cell Invasiveness through Epithelial Mesenchymal Transition Mediated by H2S/CSE Pathway. Radiat. Res. 185: 96–105, 2016.

  27. Xiangdong Wang, Jianghong Zhang*, Jiamei Fu, Juan Wang, Shuang Ye, Weili Liu, Chunlin Shao*. Role of ROS-mediated autophagy in radiation-induced bystander effect of hepatoma cells. Int. J. Radiat. Biol., 91(5): 452–458, 2015.

  28. Yuexia Xie#, Wenzhi Tu#, Jianghong Zhang, Mingyuan He, Shuang Ye, Chen Dong, Chunlin Shao*. SirT1 knockdown potentiates radiation-induced bystander effect through promotion of c-Myc activity that facilitates ROS accumulation. Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis.772: 23-29, 2015.

  29. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the malignant proliferation of hepatoma cells.  Mutat. Res. --Fundamental and Molecular Mechanisms of Mutagenesis. 763–764: 10–18, 2014.

  30. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao*.Radioprotective role of H2S/CSE pathway in Chang liver cells. Mutat. Res. --Fundamental and Molecular Mechanisms of Mutagenesis. 738-739: 12-18, 2012.

  31. Zhang J, Xie Y, Xu Y, Shao C*. Suppression of Endogenous Hydrogen Sulfide Contributes to the Radiation-Induced Bystander Effects on Hypoxic HepG2 Cells.Radiat. Res. 178: 395–402, 2012.

  32. Yuexia Xie, Jianghong Zhang, Mingyuan He, Ruiping Ren, Shuang Ye, Dexiao Yuan, Chunlin Shao*. SirT1 regulates radiosensitivity of hepatoma cells differently under normoxia and hypoxia conditions. Cancer Sci. 103(7): 1238-1244.

  33. Yuexia Xie, Jianghong Zhang, Yanwu Xu, Chunlin Shao. SirT1 confers hypoxia-induced radioprotection via the modulation of c-Myc stabilization on hepatoma cells. J. Radiat. Res., 53(1): 44-50, 2012.

  34. 张育红，邵春林，张江虹，血管生成素样蛋白在肿瘤发生发展中的作用，国际放射医学核医学杂志，43(5): 403-408，2021。

  35. 白杨，张俊玲，姚丹，张江虹，邵春林，西咪替丁对胸部分割照射小鼠脾脏损伤的治疗作用, 中华放射医学与防护杂志，40(3): 178-182，2020。

  36. 陈晓艳，张江虹，邵春林，STAT3与辐射敏感相关性的研究进展，国外放射医学与核医学杂志，40(3): 191-195，2016。

  37. 肖林林，金问森，张江虹，邵春林，电离辐射诱发动脉粥样硬化的研究进展，国际放射医学核医学杂志，39(6): 493-496, 2015。

  38. 徐金苹，袁德晓，张江虹，邵春林，辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用，国际放射医学核医学杂志，39(2): 144-148, 2015。

  39. 王向东，张江虹，邵春林，自噬与乏氧肿瘤细胞辐射抵抗，中华放射医学与防护杂志，34(2)：155-158，2014。


授权发明专利：

  1. 邵春林，袁德晓，潘燕，叶爽，张江虹，白杨，一种检测电离辐射剂量的生物学方法，申请号：201110333811.X，申请日期2011-10-28，申请公布号：CN 102508283 A，公布日：2012-6-20. 批准号：第1202428号，2013-5-29。

  2. 邵春林，郭飞，潘燕，张江虹，朱琳，张俊伶，ARL14作为肿瘤标志物在制备预测肺癌预后及靶点药物中的用途，申请号：201810780843.6，申请日期：2018年7月17日。申请公布号： CN 110714076 A，申请公布日：2020-1-21。专利授权发文序号：2022081800587050。


联系方式

上海市斜土路2094号，邮编200032；电话：021-64436075，邮箱：zjh551268@fudan.edu.cn