邵春林

发布时间：2022-09-30浏览次数：6742


个人简介

邵春林博士，二级研究员，复旦大学学术委员会委员，复旦大学基础医学学科发展中心副主任，国家重点研发计划项目首席科学家，2023中国高被引学者。先后在日本京都大学、日本国立放射医学综合研究所、英国牛津大学Gray肿瘤研究所等国外著名机构从事科研工作，致力于放射生物学、辐射信号通路与传递等方面的研究，取得了一系列创新性成果，发表论文240余篇，其中SCI论文140余篇，先后获得上海市科技进步一等奖与二等奖、上海市优秀发明金奖、中华预防医学会科学技术奖三等奖、上海医学科技奖二等奖、中国科学院自然科学奖二等奖等奖项。主持科技部重点研发计划、国家自然科学基金重点项目等省部级以上科研项目20多项，获教育部新世纪优秀人才、上海市浦江人才、上海公共卫生优秀学科带头人等人才项目支持。兼任中国生物物理学会辐射与环境生物物理专委会会长、COSPAR Associate、中国人体健康科技促进会质子重离子放射治疗专委会副主任委员、中国预防医学会放射卫生专委会副主任委员、中国核学会核应急医学分会副理事长、上海市核学会副理事长，中国抗癌协会肿瘤放射防护专委会、粒子治疗专委会、放射医学专委会常委，以及其他多个专业学会的常委；是科技部“十四五”重点研发计划重点专项、国家食品药品监督管理总局医疗器械技术审评中心的咨询专家；担任甘肃省重离子医学重点实验室学术委员会主任、多个国家实验室和国家重点实验室的学术委员会委员；Radiat. Med. Prot.副主编，Brit. J. Radiol.、J. Radiat. Res.、Front. Immunol.、Front. Oncol. 等多个国内外学术期刊的编辑。培养毕业博士、硕士毕业生40多名，其中多人获得上海市优秀毕业生称号、COSPAR杰出青年科学家论文奖、全国学术会议优秀论文奖。

2022年10月课题组合影


目前主要研究方向

  1. 超高剂量率辐射（FLASH）效应。研究FLASH效应的原初物理化学过程，研究免疫微环境在其中的作用。

  2. 肿瘤放射免疫的分子机制。主要研究肿瘤辐射抵抗的分子调控机制、免疫微环境在其中的作用。

  3. 辐射旁效应与远端效应研究。研究电离辐射非靶效应的分子信号通路与应答机制，研究免疫在其中的作用。


近年承担的主要科研项目

  1. FLASH光子放疗联合肿瘤免疫治疗的最适物理参量及生物机制研究，国家自然科学基金重点项目（2023-2027），直接经费291万。

  2. CD81/SDC1介导的免疫逃逸在胶质瘤辐射抵抗中的作用及其机制研究，国家自然科学基金项目（2022-2025），直接经费58万。

  3. 质子对肿瘤和正常组织辐射损伤模式与机理研究，上海市科委重点项目子课题（2019.9-2022.6），40万。

  4. 数字诊疗辐射生物效应及其评估新技术研究，国家重点研发计划（2017-2019），总经费2515万元，国拨经费1235万。

  5. 免疫细胞在肿瘤辐射远端效应中的作用及其分子机制研究，国家自然科学基金项目（2018-2021），直接经费60万。

  6. 外泌体在辐射远端效应中的作用及其分子机制研究，国家自然科学基金项目（2016-2019），直接经费65万。

  7. 循环miRNA在细胞辐射损伤传递中的作用，教育部博士点博导基金（2013-2015），12万。

  8. 粒子辐射损伤在多细胞体系间的传递及信号分子研究，国家自然科学基金项目（2013-2016），95万。

  9. 空间单粒子辐射危害效应及其分子机理研究，国家自然科学基金联合基金重点项目（2012-2015），280万。


代表性论文

  1. Xinglong Liu#, Yimeng Song#, Songling Hu#, Yang Bai, Jianghong Zhang, Guomei Tai*, Chunlin Shao*, Yan Pan*. Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway. Int. J. Biol. Sci. 2024 Sep 16; 20(12): 4941-4956, 2024.

  2. Yuchuan Zhou, Yuqi Xiao, Hongxia Liu, Qianping Chen, Lin Zhu, Liang Zeng, Xinglong Liu, Yan Pan, Jianghong Zhang, Jiamei Fu*, Chunlin Shao*. Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression. Am. J. Physiol. Cell Physiol. 326(1): C60-C73, 2024.

  3. Liang Zeng#, Wang Zheng#, Xinglong Liu#, Yuchuan Zhou, Xiaoya Jin, Yuqi Xiao, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes. Theranostics, 13(11):3725-3743. 2023.

  4. Junmiao Wen#, Wang Zheng#, Liang Zeng, Boyan Wang, Donglai Chen, Xinchen Sun, Yongbing Chen, Xueguan Lu, Chunlin Shao*, Jiayan Chen*, Min Fan*. LTF induces radioresistance by promoting autophagy and forms an AMPK/SP2/NEAT1/ miR-214-5p feedback loop in lung squamous cell carcinoma. Int. J. Biol. Sci. 19(5): 1509-1527, 2023.

  5. Hongxia Liu#, Qianping Chen#, Wang Zheng, Yuchuan Zhou, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. LncRNA CASC19 enhances radioresistance of nasopharyngeal carcinoma by regulating miR-340-3p/ FKBP5 axis. Int. J. Mol. Sci. 24(3): 3047, 2023.

  6. Xinglong Liu†, Liang Zeng†, Yuchuan Zhou, Xinrui Zhao, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao* and Jiamei Fu*. P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin. J. Transl. Med. 21:314, 2023.

  7. Qianping Chen#, Wang Zheng#, Jian Guan#, Hongxia Liu, Yao Dan, Lin Zhu, Yimeng Song, Yuchuan Zhou1, Xinrui Zhao, Yuhong Zhang, Yang Bai, Yan Pan*, Jianghong Zhang*, Chunlin Shao*. SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. Cell Death Differentiation. 30(1):137-151, 2023.（高被引论文）

  8. Wang Zheng†, Qianping Chen†, Hongxia Liu, Liang Zeng, Yuchuan Zhou, Xinglong Liu, Yang Bai, Jianghong Zhang*, Yan Pan*, Chunlin Shao*. SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes. Autophagy, 19(3):839-857, 2023.

  9. Xiaolin Shi†, Yiwei Yang†, Wei Zhang†, Jianxin Wang†, Dexin Xiao, Huangge Ren, Tingting Wang, Feng Gao, Zhen Liu, Kui Zhou, Peng Li, Zheng Zhou, Peng Zhang, Xuming Shen, Yu Liu, Jianheng Zhao, Zhongmin Wang, Fenju Liu, Chunlin Shao, Dai Wu*, Haowen Zhang*. FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy. Proc. Natl. Acad. Sci. USA 119(43): e2208506119, 2022.

  10. Xinrui Zhao, Xinglong Liu, Songling Hu, Yan Pan, Jianghong Zhang, Guomei Tai,* and Chunlin Shao*. GDF15 contributes to radioresistance by mediating the EMT and stemness of breast cancer cells. Int. J. Mol. Sci., 23: 10911, 2022.

  11. Yuhong Zhang, Xinglong Liu, Liang Zeng, Xinrui Zhao, Qianping Chen, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment. Brit. J. Cancer. 127(10): 1760-1772, 2022.

  12. Xinrui Zhao, Xinglong Liu, Songling Hu, Yan Pan, Jianghong Zhang, Guomei Tai,* and Chunlin Shao*. GDF15 contributes to radioresistance by mediating the EMT and stemness of breast cancer cells. Int. J. Mol. Sci., 23(18), 10911, 2022.

  13. Xinrui Zhao#, Songling Hu#, Liang Zeng, Xinglong Liu, Yimeng Song, Yuhong Zhang, Qianping Chen1, Yang Bai1, Jianghong Zhang1, Haowen Zhang*, Yan Pan*, Chunlin Shao*. Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated Tcell activation. iScience, 25: 104690, 2022.

  14. Xinglong Liu, Chunlin Shao* and Jiamei Fu*. Promising Biomarkers of Radiation-Induced Lung Injury: A Review. Biomedicines, 9(9): 1181, 2021.

  15. Yuchuan Zhou, Hongxia Liu, Wang Zheng, Qianping Chen, Songling Hu, Yan Pan, Yang Bai, Jianghong Zhang* and Chunlin Shao*. MMP14 contributes to HDAC inhibition-induced radiosensitization of glioblastoma. Int. J. Mol. Sci., 22(19): 10403, 2021.

  16. Yimeng Song#, Songling Hu#, Junling Zhang, Lin Zhu, Xinrui Zhao, Qianping Chen, Jianghong Zhang, Yang Bai, Yan Pan*, Chunlin Shao*. Fractionated irradiation of right thorax induces abscopal damage on bone marrow cells via TNF-α and SAA. Int. J. Mol. Sci., 22(18): 9964, 2021.

  17. Qianping Chen#, Wang Zheng#, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. LACTB2 Renders Radioresistance by Activating PINK1/Parkin-dependent Mitophagy in Nasopharyngeal Carcinoma Cells. Cancer Letters. 518: 127–139, 2021.

  18. Wang Zheng#, Qianping Chen#, Hongxia Liu, Songling Hu, Yuchuan Zhou, Yang Bai, Jianghong Zhang, Yan Pan and Chunlin Shao*. CD81 enhances radioresistance of glioblastoma by promoting nuclear translocation of Rad51. Cancers, 13:1998, 2021.

  19. Jianghong Zhang, Yuhong Zhang, Fang Mo, Gaurang Patel, Karl T Butterworth, Chunlin Shao*, Kevin Prise*. The roles of HIF-1α in radiosensitivity and radiation induced bystander effects under hypoxia. Front. Cell Develop. Biol., 9: 637454, 2021.

  20. Songling Hu#, Lin Zhu#, Yimeng Song#, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang*, Chunlin Shao*. Radiation-induced abscopal reproductive effect is driven by Rac1 nuclear translocation in Sertoli cells. Theranostics. 11(12): 5742-5758, 2021.

  21. Lin Zhu#, Songling Hu#, Qianping Chen, Jiamei Fu, Haowen Zhang, Junling Zhang, Yan Pan, Yang Bai, Chunlin Shao*. Roles of macrophage in radiation-induced abscopal effect via TNF-α in breast cancer. Int. J. Biol. Sci., 17(4): 926-941, 2021.

  22. Hongxia Liu, Wang Zheng, Qianping Chen, Yuchuan Zhou, Yan Pan, Jianghong Zhang, Yang Bai and Chunlin Shao*. LncRNA CASC19 contributes to radioresistance of nasopharyngeal carcinoma by promoting autophagy via AMPK-mTOR pathway. Int. J. Mol. Sci. 22(3), 1407, 2021.

  23. Yuchuan Zhou, Chunlin Shao*. Histone methylation can either promote or reduce cellular radiosensitivity by regulating DNA repair pathways. Mut. Res. Review. 787: 108362, 2021.

  24. Han Pan, Yimeng Song, Hang Zhang, Yang Bai, Teruaki Konishi, Alisa Kobayashi, Yan Pan*, Chunlin Shao*. Radiation engenders conversed migration and invasion in colorectal cancer cells through opposite modulation of ANXA2/ AKT /GSK3β pathway. Am. J. Cancer Res., 11(1): 61-78, 2021.

  25. Xinrui Zhao, Chunlin Shao*. Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade. Cancers, 12, 2762, 2020.

  26. Xiaofei Chu, Wang Zheng, Juan Wang, Jianghong Zhang, Yan Pan and Chunlin Shao. CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation. Biochem. Biophys. Res. Commun., 531: 328-334, 2020.

  27. Fei Chen#, Yushuo Zhang#, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang*, Chunlin Shao*. Induction of TIGAR accelerates reserve intestinal stem cell division and mitigates lethal gastrointestinal syndrome induced by radiation. Cell Death Dis., 11: 501, 2020.

  28. Lin Zhu, Qianping Chen, Longshan Zhang, Songling Hu, Wang Zheng, Chen Wang, Yang Bai, Yan Pan, Teruaki Konishi, Jian Guan*, Chunlin Shao*. CLIC4 regulates radioresistance of nasopharyngeal carcinoma by iNOS after γ-rays but not carbon ions irradiation. Am. J. Cancer Res., 10(5): 1400–1415, 2020.

  29. Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. Exosomes from irradiated lung cancer cells carrying ALDOA and ALDH3A1 enhance migration and invasion of recipients by accelerating glycolysis. Mol. Cell. Biochem., 469: 77–87, 2020.

  30. Fang Mo, Yanwu Xu, Junling Zhang, Lin Zhu, Chen Wang, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Effects of hypoxia and radiation-induced exosomes on migration of lung cancer cells and angiogenesis of umbilical vein endothelial cells. Radiat. Res., 194: 71–80, 2020.

  31. Wang Zheng#, Qianping Chen#, Chen Wang, Xiaofei Chu, Dan Yao, Lin Zhu, Yan Pan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Inhibition of Cathepsin D (CTSD) enhances radiosensitivity in glioblastoma cells through attenuated autophagy. Mol. Carcinogen., 59: 651–660. 2020.

  32. Qianping Chen#, Wang Zheng#, Lin Zhu, Dan Yao, Junling Zhang ,Chen Wang, Fang Mo, Yimeng Song, Hongxia Liu, Songling Hu, Xiaofei Chu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. ANXA6 contributes to radioresistance by regulating cell autophagy and migration in nasopharyngeal carcinoma. Front. Cell Develop. Biol., 8: 232, 2020.

  33. Jiamei Fu, Lin Zhu, Wenzhi Tu, Xiangdong Wang, Yan Pan, Yang Bai, Bingrong Dang, Jieyi Chen, Chunlin Shao*. Macrophage-mediated secondary bystander effects after different radiations through a p53-dependent pathway. Radiat. Res., 193:119-129, 2020。

  34. Chen Dong#, Wenzhi Tu#, Mingyuan He, Jiamei Fu, Alisa Kobayashi, Yoshiya Furusawa, Teruaki Konishi*, Chunlin Shao*. Role of endoplasmic reticulum and mitochondrion in proton microbeam-irradiation induced bystander effect. Radiat. Res., 193: 63-72, 2019.

  35. Fei Guo, Dexiao Yuan, Junling Zhang, Hang Zhang, Chen Wang, Lin Zhu, Jianghong Zhang, Yan Pan* and Chunlin Shao*. Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State. Front. Cell Develop. Biol., 7: 238, 2019.

  36. Junling Zhang, Dan Yao, Yimeng Song, Yan Pan, Lin Zhu, Yang Bai, Yanwu Xu, Jianghong Zhang*, Chunlin Shao*. Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility. Sci. Rep., 9: 15221, 2019.

  37. Junling Zhang, Dan Yao, Jianghong Zhang, Yimeng Song, Fang Mo, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao*. TGF-β mediates thoracic radiation-induced abscopal effects of testis injury in rat. Biochem. Biophys. Res. Commun., 514(3): 678-683, 2019.

  38. Xiangdong Wang, Wenzhi Tu, Chen Dong, Jiamei Fu, Juan Wang, Chunlin Shao*, Jianghong Zhang*. Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells. Int. J. Radiat. Biol. 95(8): 1051-1057, 2019.

  39. Wenzhi Tu, Chen Dong, Jiamei Fu, Yan Pan, Alisa Kobayashi, Yoshiya Furusawa, Teruaki Konishi and Chunlin Shao*. Both irradiated and bystander effects link with DNA repair capacity and the linear energy transfer. Life Sci., 222: 228-234, 2019.

  40. Hang Zhang, Yimeng Song, Cuiping Zhou, Yang Bai, Dexiao Yuan, Yan Pan*, Chunlin Shao*. Blocking endogenous H2S signaling attenuated radiation-induced long-term metastasis of residual HepG2 cells through inhibition of EMT. Radiat. Res. 190(4): 374-384, 2018.

  41. Yuexia Xie, Shuang Ye, Jianghong Zhang, Mingyuan He, Dexiao Yuan, Chunlin Shao*. Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells. Sci. Rep., 6:38832, 2016.

  42. Jiamei Fu, Juan Wang, Xiangdong Wang, Ping Wang, Jinping Xu, Cuiping Zhou, Yang Bai, Chunlin Shao*. Signaling factors and pathways of α-particle irradiation induced bilateral bystander responses between Beas-2B and U937 cells. Mutat. Res.-Fund. Mol. Mech. Mutagen. 789: 1-8. 2016.

  43. Juan Wang, Jinping Xu, Jiamei Fu, Dexiao Yuan, Fei Guo, Cuiping Zhou and Chunlin Shao*. MiR-29a Regulates Radiosensitivity in Human Intestinal Cells by Targeting PTEN Gene. Radiat. Res. 186: 292–301, 2016.

  44. Pan, Y., Zhou, C., Yuan, D., Zhang, J. and Shao C*. Radiation Promotes Hepatocarcinoma Cell Invasiveness through Epithelial Mesenchymal Transition Mediated by H2S/CSE Pathway. Radiat. Res. 185: 96–105, 2016.

  45. Jiamei Fu, Dexiao Yuan, Linlin Xiao, Wenzhi Tu, Chen Dong, Weili Liu, Chunlin Shao*. The crosstalk between α-irradiated Beas-2B cells and its bystander U937 cells through MAPK and NF-κB signaling pathways. Mutat. Res.-Fund. Mol. Mech. Mutagen., 783:1-8. 2016.

  46. Wenzhi Tu, Chen Dong, Teruaki Konishi, Alisa Kobayashi, Yoshiya Furusawa, Yukio Uchihori, Yuexia Xie, Bingrong Dang, Wenjian Li and Chunlin Shao*. G2-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation. Mutat. Res.-Gen. Toxic. Environ. Mutagen., 795: 1–6, 2016.

  47. Chen Dong, Mingyuan He, Wenzhi Tu, Teruaki Konishi, Weili Liu, Yuexia Xie, Bingrong Dang, Wenjian Li, Yukio Uchihori, Tom K. Hei, Chunlin Shao*. The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation. Cancer Letters, 363: 92-100, 2015.

  48. Chen Dong, Mingyuan He, Ruiping Ren, Yuexia Xie, Dexiao Yuan, Bingrong Dang, Wenjian Li, Chunlin Shao*. Role of MAPK pathway in the bystander effect on lymphocytes co-cultured with macrophages irradiated with -rays and carbon ions. Life Sci. 127: 19-25, 2015.

  49. Xiangdong Wang, Jianghong Zhang*, Jiamei Fu, Juan Wang, Shuang Ye, Weili Liu, Chunlin Shao*. Role of ROS-mediated autophagy in radiation-induced bystander effect of hepatoma cells. Int. J. Radiat. Biol., 91(5): 452–458, 2015.

  50. Yuexia Xie, Wenzhi Tu, Jianghong Zhang, Mingyuan He, Shuang Ye, Chen Dong, Chunlin Shao*. SirT1 knockdown potentiates radiation-induced bystander effect through promotion of c-Myc activity that facilitates ROS accumulation. Mutat. Res.-Fund. Mol. Mech. Mutagen., 772: 23-29, 2015.

  51. Shuang Ye, Dexiao Yuan, Yuexia Xie, Yan Pan, Chunlin Shao*. Role of DNA methylation in the adaptive responses induced in a human B lymphoblast cell line by long-term low-dose exposures to γ-rays and cadmium. Mutat. Res.—Gen. Toxic. Environ. Mutagen., 773: 34–38, 2014.

  52. Linlin Xiao, Weili Liu, Jitao Li, Yuexia Xie, Mingyuan He, Jiamei Fu, Wensen Jin and Chunlin Shao*. Irradiated U937 cells trigger inflammatory bystander responses in human umbilical vein endothelial cells through the p38 pathway. Radiat. Res. 182: 111-121, 2014.

  53. Weili Liu, Linlin Xiao, Chen Dong, Mingyuan He, Yan Pan, Yuexia Xie, Wenzhi Tu, Jiamei Fu, Chunlin Shao*. Long-term low-dose a-particle enhanced the potential of malignant transformation in human bronchial epithelial cells through MAPK/Akt pathway. Biochem. Biophys. Res. Commun., 447(3): 388-393, 2014.

  54. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the malignant proliferation of hepatoma cells. Mutat. Res.-Fund. Mol. Mech. Mutagen., 763-764: 10-18, 2014.

  55. Mingyuan He, Yuexia Xie, Chen Dong, Jitao Li, Dexiao Yuan, Yang Bai, Chunlin Shao*. Reciprocal bystander effect between α-irradiated macrophage and vicinal hepatocyte is mediated by cAMP communication through a membrane signaling pathway. Mutat. Res.-Fund. Mol. Mech. Mutagen., 763-764: 1-9, 2014.

  56. Minyuan He, Chen Dong, Teruaki Konishi, Wenzhi Tu, Weili Liu, Naoko Shiomi, Alisa Kobayashi, Yukio Uchihori, Yoshiya Furusawa, Tom K Hei, Bingrong Dang, Chunlin Shao*. Differential effects of p53 on bystander phenotypes induced by gamma-ray and high LET heavy ion radiation. Life Sci. Space Res., 1: 53-59, 2014.

  57. Shuang Ye, Dexiao Yuan, Yuexia Xie, Yan Pan, Chunlin Shao*. Role of DNA methylation in long-term low-dose γ-radiation induced adaptive response in human B lymphoblast cells. Int. J. Radiat. Biol., 89(11): 898-906, 2013.

  58. Mingyuan He, Ruiping Ren, Dexiao Yuan, Yuexia Xie, Yan Pan, Chen Dong and Chunlin Shao*. Radiation enhances the invasiveness of irradiated and nonirradiated bystander hepatoma cells through a VEGF-MMP2 pathway initiated by p53. Radiat. Res. 180(4): 389-97, 2013.

  59. Dexiao Yuan, Shuang Ye, Yan Pan, Yizhong Bao, Honghong Chen, Chunlin Shao*. Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation. Mutat. Res.-Fund. Mol. Mech. Mutagen., 757(2):125-31, 2013.

  60. Ruiping Ren, Mingyuan He, Chen Dong, Yuexia Xie, Shuang Ye, Dexiao Yuan, Chunlin Shao*. Dose response of micronuclei induced by combination radiation of a-particles and r-rays in human lymphoblast cells. Mutat. Res.-Fund. Mol. Mech. Mutagen., 741-742: 51-56. 2013.

  61. Yu W#, Gu K#, Yu Z, Yuan D, He M, Ma N, Lai S, Zhao J, Ren Z, Zhang X, Shao C, Jiang GL*. Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo. Cancer Lett. 329(1): 109-17, 2013.

  62. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Radioprotective role of H2S/CSE pathway in Chang liver cells. Mutat. Res.-Fund. Mol. Mech. Mutagen., 738-739: 12-18, 2012.

  63. Zhang J, Xie Y, Xu Y, Shao C*. Suppression of endogenous hydrogen sulfide contributes to the radiation-induced bystander effects on hypoxic HepG2 cells. Radiat. Res., 178: 395–402, 2012.

  64. Kai Lei, Xiaoqiang Zhu, Rener Xu, Chunlin Shao, Tian Xu, Yuan Zhuang, Min Han. Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response. Current Biology. 22(17): 1609-15, 2012.

  65. Yuexia Xie, Jianghong Zhang, Mingyuan He, Ruiping Ren, Shuang Ye, Dexiao Yuan, Chunlin Shao*. SirT1 regulates radiosensitivity of hepatoma cells differently under normoxia and hypoxia conditions. Cancer Sci. 103(7): 1238-1244, 2012.

  66. Mingyuan He, Shuang Ye, Ruiping Ren, Chen Dong, Yuexia Xie, Dexiao Yuan, Chunlin Shao*. Cytochrome-c mediated a bystander response dependent on inducible nitric oxide synthase in irradiated hepatoma cells. Brit. J. Cancer. 106(5): 889-95, 2012.

  67. Jianghong Zhang, Yuexia Xie, Yanwu Xu, Yan Pan, Chunlin Shao*. Hydrogen Sulfide Contributes to Hypoxia-Induced Radioresistance on Hepatoma cells. J. Radiat. Res., 52(5):622-628. 2011.

  68. Yan Pan, Dexiao Yuan, Jianghong Zhang, Chunlin Shao*. Cadmium induced radioadaptive response via ATM-independent H2S/cystathionine γ-lyase modulation. Mutat. Res.-Fund. Mol. Mech. Mutagen., 707(1-2): 67-73, 2011.

  69. Mingyuan He, Meijia Zhao, Bo Shen, Kevin M Prise, Chunlin Shao*. Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cells. Oncogene, 30: 1947–1955, 2011. (IF 7.2)

  70. Dexiao Yuan, Yan Pan, Jianghong Zhang, Chunlin Shao. Role of nuclear factor-κB and P53 in radioadaptive response in Chang live cells. Mutat. Res.-Fund. Mol. Mech. Mutagen., 688: 66-71, 2010.

  71. Yan Pan, Dexiao Yuan, Junxiang Zhang, Ping Xu, Honghong Chen, Chunlin Shao*. Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity. Radiat. Res. 171(4): 446-453, 2009.

  72. Chunlin Shao, Melvyn Folkard, Kathryn D. Held, and Kevin M. Prise*. Estrogen enhanced cell-cell signalling in breast cancer cells exposed to targeted irradiation. BMC Cancer, 8:184, 2008.

  73. Chunlin Shao, Melvyn Folkard and Kevin M. Prise*. Role of TGF-b1 and nitric oxide in bystander response on targeted glioma cells. Oncogene, 27(4): 434-440, 2008.

  74. Chunlin Shao, Kevin M. Prise, Melvyn Folkard. Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts. Mutat. Res.-Fund. Mol. Mech. Mutagen., 638 (1-2): 139-145, 2008.

  75. Chunlin Shao*, Yoshiya Furusawa, Yoshitaka Motsumoto, Yan Pan, Ping Xu, Honghong Chen. Effect of Gap Junctional Intercellular Communication on Radiation Responses in Human Neoplastic Cells. Radiat. Res. 167(3): 283-288, 2007.

  76. Chunlin Shao, Fiona M. Lyng, Melvyn Folkard, Barry D. Michael and Kevin M. Prise*. Calcium fluxes modulate targeted radiation induced bystander responses in glioma and fibroblast cells. Radiat. Res. 166: 479-487, 2006.

  77. Chunlin Shao, Melvyn Folkard, Barry D. Michael, Kevin M. Prise*. Bystander signalling between glioma cells and fibroblasts targeted with counted particles. Int. J. Cancer, 116, 45-51, 2005.

  78. Chunlin Shao, Melvyn Folkard, Barry D. Michael, and Kevin M. Prise*. Targeted cytoplasmic irradiation induces bystander responses. Proc. Natl. Acad. Sci. USA 101, 13495-13500, 2004.

  79. Chunlin Shao, V. Stewart, M. Folkard, B. D. Michael, and K. M. Prise*. Nitric oxide-mediated signalling in the bystander response of individually targeted glioma cells. Cancer Res., 163, 8437-8442, 2003.

  80. Chunlin Shao, Yoshiya Furusawa*, Yasuhiko Kobayashi, Tomoo Fnnayama and Seiichi Wada. Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. FASEB J., 17: 1422-1427, 2003.

  81. Chunlin Shao, Yoshiya Furusawa*, Mizhuo Aoki and Koichi Ando. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat. Res., 160: 318-323, 2003.

  82. Chunlin Shao, Mizhuo Aoki, Yoshiya Furusawa*. Nitric oxide-induced revisable proliferation inhibition and cycle arrests associated with a micronucleus induction in HSG cells. Nitric Oxide, 8: 83-88, 2003.

  83. Chunlin Shao, Yoshiya Furusawa*, Mizhuo Aoki, Hideki Matsumoto, Koichi Ando. Nitric oxide-mediated bystander effect induced by heavy-ion radiation in human salivary gland neoplastic cells. Int. J. Radait. Biol. 78: 837-844, 2002.


授权发明专利

  1. 邵春林，朱琳，陈倩萍，CLIC4在制备放射治疗鼻咽癌制剂中的应用，专利号：ZL201910615916.0.

  2. 邵春林，郭飞，潘燕，张江虹，朱琳，张俊玲，ARL14作为肿瘤标志物在制备预测肺癌预后及靶点药物中的用途，专利号：ZL201810780843.6.

  3. 张昊文，邵春林，王忠敏，林龙昕，石小林，陈飞，刘芬菊，TIGAR基因或蛋白在制备放射性胃肠综合征救治药物中的应用，专利号：ZL202010334894.3.

  4. 邵春林，袁德晓，潘燕，叶爽，张江虹，白杨，一种检测电离辐射剂量的生物学方法, 专利号：ZL201110333811X.


科技服务

辐射生物剂量评估：开展放射性从业人员辐射生物剂量的检测与评估等科技服务工作。


联系方式

上海市斜土路2094号，邮编200032；电话：021-64048677；邮箱：clshao@shmu.edu.cn