徐小雅，女，1980年8月生，中共党员，复旦大学放射医学研究所高级实验师，山东省医学会类器官分会委员。2007年毕业于复旦大学，2015年7月-2016年7月美国路易斯安那州立大学干细胞中心访问学者。承担国家自然科学基金项目，中央高校自然科学项目，山东省类器官重点研发计划，参与上海市科委重点项目。主要从事类器官原代分离培养，肿瘤类器官体外药敏体系建立与临床肿瘤病人预后相关性研究。通过手术标本，活检标本和穿刺标本已建立结直肠癌，胰腺癌，卵巢癌，肺癌，乳腺癌，膀胱癌，肝癌等原位肿瘤类器官300余例，并进行直肠癌类器官敏感性与病人新辅助治疗预后相关性研究，成果发表于Cell Stem Cell。参与申请发明专利10项，已授权3项。
科研项目
1. 2022山东省重大研发计划，类器官构建及器件化融合功能关键技术研发与应用（子课题：建立基于类器官技术的药敏、放敏等临床应用体系），2023/01/01-2025/12/30。
2. 国家自然科学基金面上项目，82173461，CBP/P300 抑制剂促进肠道辐射损伤后再生机理研究，2022/01/01-2025/12/30。
3. 国家自然科学基金面上项目，82071581，Gal-3/CD36 相互作用在衰老微环境- 肝细胞代谢驱动网络中作用，2021/01/01-2024/12/30。
4. 国家自然科学基金面上项目，81972971，TRPML1协同Syntaxin3/4调控溶酶体极性胞吐对肾铀的促排作用研究，2020/01/01-2023/12/30。
5. 国家自然科学基金面上项目，31670858，潘氏细胞调控肠道干细胞DNA辐射损伤修复能力的机理研究，2016/01/01-2019/12/30。
6. 复旦大学青年教师科研能力提升项目，20520133100，辐射对淋巴细胞与成骨细胞相互作用的影响， 2013 /1/1-2014/12/30。
7. 国家自然科学基金青年项目，81102071，免疫细胞在放射性骨损伤间接效应中的作用与机制，2012/1/1-2014/12/30。
8. 国家自然科学基金青年项目，30900698，PPARɣ-GSK3β 信号通路在 TZDs 类抗糖尿病药物抑制成骨细胞骨形成中的机制研究，2010/01/01-2012/12/30。
9. 国家自然科学基金面上项目，10975034，核微探针技术研究锶离子在骨代谢中的作用，2010/01/01-2013/12/30。
专利授权
1. CBP-P300抑制剂在肠道损伤疾病中的应用（授权号：CN110170052B,专利号：ZL201910541233.5）
2. 一种基于局部照射的全身性骨损伤模型的建立及病理机制分析的方法（专利号：201710707903.7）
3. SIRT1抑制剂用于预防和治疗放射引起的口腔损伤（授权公告号：CN10974563B）
论文列表
1. Guan R, Pan M, Xu X#,Du L, Rao X, Fu G, Lv T, Zhang L, Li Y, Tang P, Zhou Y, Wang Y, Zhang Z, Gao J, Zhou H, Mi W, Hua G. Interleukin-33 potentiates TGF-b signaling to regulate intestinal stem cell regeneration after radiation injury. Cell Transplant. 2023 Jan-Dec; 32:9636897231177377.
2. Lv T, Shen L, Xu X#, Yao Y, Mu P, Zhang H, Wan J, Wang Y, Guan R, Li X, Fu G, Zhang L, Wang Y, Xia F, Hu C, Clevers H, Zhang Z, Hua G. Patient-derived tumor organoids predict responses to irinotecan-based neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer. Int J Cancer. 2023 Feb 1;152(3):524-535
3. Mo S, Tang P, Luo W, Zhang L, Li Y, Hu X, Ma X, Chen Y, Bao Y, He X, Fu G, Xu X, Rao X, Li X, Guan R, Chen S, Deng Y, Lv T, Mu P, Zheng Q, Wang S, Liu F, Li Y, Sheng W, Huang D, Hu C, Gao J, Zhang Z, Cai S, Clevers H, Peng J, Hua G. Patient-derived organoids from colorectal cancer with paired liver metastasis reveal tumor heterogeneity and predict response to chemotherapy. Adv Sci (Weinh), 2022 Sep 4:2204097.
4. Li X, Fu G, Zhang L, Guan R, Tang P, Zhang J, Rao X, Chen S, Xu X, Zhou Y, Deng Y, Lv T, He X, Mo S, Mu P, Gao J, Hua G. Assay establishment and validation of a high-throughput organoid-based drug screening platform. Stem Cell Res Ther. 2022 May 26;13(1):219.
5. Hong W, Tang L, Ge R, Li W, Shen X, Hong L, Xu X*. Persistent abnormal immunocytes induced systemic bone loss in locally irradiated rats. Calcif Tissue Int, 2021 Dec; 109(6):706-718.
6. Rao X, Tang P, Li Y, Fu G, Chen S, Xu X, Zhou Y, Li X, Zhang L, Mo S, Cai S, Peng J, Zhang Z, Gao J, Hua G. CBP/P300 inhibitors mitigate radiation-induced GI syndrome by promoting intestinal stem cell-mediated crypt regeneration. Int J Radiat Oncol Biol Phys. 2021 Jul 15;110(4):1210-1221.
7. Li Y, Rao X, Tang P, Chen S, Guo Q, Fu G, Pan M, Liang L, Yao Y, Gao X, Zhou Y, Zhang Z, Xu X, Hu W, Gao J, Hua G. Bach2 deficiency promotes intestinal epithelial regeneration by accelerating DNA repair in intestinal stem cells. Stem Cell Reports, 2021 Jan 12;16(1)120-133.
8. Fu G, Chen S, Liang L, Li X, Tang P, Rao X, Pan M, Xu X, Li Y, Yao Y, Zhou Y, Gao J, Mo S, Cai S, Peng J, Zhang Z, Clevers H, Gao J, Hua G. SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal stem-cell survival. Cancer Lett. 2021 Mar 31;501:20-30.
9. Ye Yao, Xiaoya Xu#, Lifeng Yang, Ji Zhou, Juefeng Wan, Lijun Shen, Fan Xia, Guoxiang Fu, Yun Deng, Menxue Pan, Qiang Guo, Xiaoxue Gao, Yuanchuang Li, Xinxin Rao, Yi Zhou, Liping Liang, Yaqi Wang, Jing Zhang, Hui Zhang, Lixing Zhang, Junjie Peng, Sanjun Cai, Chen Hu, Jianjun Gao, Hans Clevers, Zhen Zhang, Guoqiang Hua. Patient-derived organoids predict chemoradiation responses of locally advanced rectal cancer. Cell Stem Cell. 2020 Jan 2;26(1):17-26.
10. Li Y, Li J, Wang R, Zhang L, Fu G, Wang X, Wang Y, Fang C, Zhang D, Du D, Ma X, Pan M, Guo Q, Xu X, Hu X, Zhou Y, Mo S, Wang H, Gao J, Huang S, Liu Y, Cao S, Hua G, Peng J, Yu FX. Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma. Protein Cell. 2020 Apr;11(4)292-298.
11. Hu X, Zhang L, Li Y, Ma X, Dai W, Gao X, Rao X, Fu G, Wang R, Pan M, Guo Q, Xu X, Zhou Y, Gao J, Zhang Z, Cai S, Peng J, Hua G. Organoid modelling identifies that DACH1 functions as a tumor promoter in colorectal cancer by modulating BMP signaling. EBioMedicine. 2020 Jun; 56:102800.
12. Li Y, Wang R, Huang D, Ma X, Mo S, Guo Q, Fu G, Li Y, Xu X, Hu X, Zhou Y, Deng Y, Zhang L, Chen H, Gao J, Zhang Z, Cai S, Hua G, Peng J. A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application. Carcinogenesis, 2020 Jul 14;41(7):993-1004.
13. Hong W, Wei Z, Qiu Z, Li Z, Fu C, Ye Z, Xu X*. Atorvastatin promotes bone formation in aged apoE-/- mice through the Sirt1-Runx2 axis. J Orthop Surg Res. 2020 Aug 6;15(1):303.
14. Zhang L, Mo S, Hu X, Ma X, Jin W, Peng DH, Zhou Y, Liang X, Rao X, Xu X, Zhang Z, Hua G, Cai S, Li Y, Peng J. Establishment and identification of organoids from human circulating colorectal cancer cells. Clin Transl Med. 2020 Dec;10(8):e247.
15. Guo Q, Chen S, Rao X, Li Y, Pan M, Fu G, Yao Y, Gao X, Tang P, Zhou Y, Xu X, Gao J, Hua G. Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation induced oral mucositis in mice. Am J Transl Res,2019 Aug 15;11(8):4789-4799.
16. Mengxue Pan, Wei Hong, Ye Yao, Xiaoxue Gao, Yi Zhou, Guoxiang Fu,Yuanchuang Li, Qiang Guo, Xinxin Rao, Peiyuan Tang, Shengzhi,Chen, Weifang Jin, Guoqiang Hua, Jianjun Gao and Xiaoya Xu*. Activated B lymphocyte inhibited the osteoblastogenesis of bone mesenchymal stem cells by Notch signaling. Stem Cell Int,2019 Jun 2;2019:8150123.
17. Xiaoya Xu#, Ruixia Li, Yi Zhou, Qiong Zou, Qiaoling Ding, Jinfeng Wang, Weifang Jin, Guoqiang Hua, Jianjun Gao*. Dysregulated systemic lymphocytes affect the balance of osteogenic/adipogenic differentiation of bone mesenchymal stem cells after local irradiation. Stem Cell Res Ther, 2017,8(1):71
18. Changjun Guo#, Changwei Li, KaiYang, Xiaoya Xu*, Xiangyang Xu*, Lianfu Deng*. Increased EZH2 and decreased osteoblastogenesis during local irradiation-induced bone loss in rats. Scientific Reports, 2016,6:31318
19. Qiong Zou#, Wei Hong,Yi Zhou, Qiangling Ding, Jinfeng Wang, Weifang Jin, Jianjun Gao, Guoqiang Hua, Xiaoya Xu*. Bone marrow stem cell dysfunction in radiation-induced abscopal bone loss. Journal of Orthopaedic Surgery and Research. 2016,11:3
20. Wei Hong#, Xiaoya Xu, Zhaohui Qiu, Jianjun Gao, Zhanying Wei, Zhen Li, Xiaoli Zhang, Zhibing Ye*. Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice. Acta Pharmacologica Sinica. 2015,36(12):1487-96
联系方式
上海市徐汇区斜土路2094号1号实验大楼407室，邮编：200032；
电话：021-64048126 (13774257863)；
邮箱：xiaoyaxu@fudan.edu.cn
