科学研究
陈红红
 

陈红红,复旦大学放射医学研究所研究员(三级),硕士研究生导师。20097月至20107月在美国圣路易斯华盛顿大学医学院放射肿瘤系作访问学者。主持国家科技重大专项子课题、国家自然科学基金面上项目、上海市科委重点项目等多项课题,发表科研论文60余篇,其中SCI论文20余篇;先后获得军队科技进步二等奖1项(第三完成人)和上海市科技成果1项(第一完成人);以第一发明人获得国家发明专利授权2项;作为共同主编和副主编编著学术著作3部,参编著作4部。目前是国家卫生健康标准委员会放射卫生标准专业委员会(放射性疾病诊断组)委员、中国毒理学会放射毒理专业委员会委员、辐射与环境生物物理专业委员会委员、上海市核学会实验核医学与核药学专业委员会委员和《中华放射医学与防护杂志》编委等。

 20196月课题组合影


主要研究方向:

1)辐射损伤诊断和防治研究:主要包括辐射生物剂量计、造血系统辐射损伤效应/机制/辐射防护剂和放射性核素促排药物研究;

2)肿瘤放射敏感性研究:主要为乳腺癌放射增敏靶点及放射增敏剂的药效/机制研究。


科技服务:

1)放射工作人员染色体畸变检查及辐射生物剂量估算;

2)辐射防护剂、放射性核素促排药物和肿瘤放射增敏剂的药效及机制研究。


代表性的论文:

1Ren XHuo MWang MLin HZhang XYin JChen Y*, Chen H*. Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging. ACS Nano, 2019, 13(6):6438-6454

2Yin L, Gao Y, Zhang X, Wang J, Ding D, Zhang Y, Zhang J, Chen H*. Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling. Oncotarget, 2016, 7(27):42126-42138

3)Ding D, Zhang Y, Wang J, Wang X, Fan D, He L, Zhang X, Gao Y, Li Q, Chen H*. γ-H2AX/53BP1/pKAP-1 foci and their linear tracks induced by in vitro exposure to radon and its progeny in human peripheral blood lymphocytes. Scientific Reports, 2016, 6:38295

4)Wang J, He L, Fan D, Ding D, Wang X, Gao Y, Zhang X, Li Q, Chen H*. Establishment of a γ-H2AX focibased assay to determine biological dose of radon to red bone marrow in rats. Scientific Reports, 2016, 6:30018

5Wang J, Yin L, Zhang J, Zhang Y, Zhang X, Ding D, Gao Y, Li Q, Chen H*. The profiles of gamma-H2AX along with ATM/DNA-PKcs activation in the lymphocytes and granulocytes of rat and human blood exposed to gamma rays. Radiation and Environmental Biophysics, 2016, 55(3):359-370

6Ding D, Zhang Y, Wang J, Zhang X, Gao Y, Yin L, Li Q, Li J and Chen H*. Induction and inhibition of the pan-nuclear gamma-H2AX response in resting human peripheral blood lymphocytes after X-ray irradiation. Cell Death Discovery, 2016, 2:16011

7Bao Y, Wang D, Hu Y, Xu A, Chen H*. Efficacy of chelator CBMIDA-CaNa2 for the removal of uranium and protection against uranium-induced cell damage in human renal proximal tubular cells.Health physics, 2013, 105(1):31-38.

8Bao Y, WangD, Li Z, Hu Y, Xu A, Wang Q, Shao C, Chen H*. Efficacy of a novel chelator BPCBG for removing uranium and protecting against uranium-induced renal cell damage in rats and HK-2 cells. Toxicology and Applied Pharmacology, 2013, 269(1):17-24.

9Bao Y, Chen H*, Hu Y, Bai Y, Zhou M, Xu A, Shao C. Combination effects of chronic cadmium exposure and gamma-irradiation on the genotoxicity and cytotoxicity of peripheral blood lymphocytes and bone marrow cells in rats. Mutatation Research, 2012.743(1-2):67-74

10Chen H*, Bao Y, Yu L, Jia R, Cheng W and Shao C. Comparison of cellular damage response to low-dose-rate 125I seeds irradiation and high-dose-rate gamma irradiation in human lung cancer cells. Brachytherapy, 2012, 11(2):149-156

11Chen H, Ma Z, Vanderwaal RP, Feng Z, Gonzalez-Suarez I, Wang S, Zhang J, Roti Roti JL, Gonzalo S and Zhang J*. The mTOR inhibitor rapamycin suppresses DNA double-strand break repair. Radiation Research, 2011,175(2):214-224


授权发明专利:

1)陈红红,暴一众,王丹,胡昱兴,徐爱红,化合物[2,3-二羟基-1,4-苯撑]二胺四乙酸盐及其药用组合物和应用,2016.03.30,中国,201210497250.1

2)陈红红,孙梅贞,罗梅初,暴一众,王丹,胡昱兴,徐爱红,N,N'-1,2-亚乙基[N-(2,3-二羟基苯甲基)]甘氨酸及其衍生物在制药中的用途,2014.06.11,中国,201110346956.3


联系方式

上海市斜土路2094号,邮编:200032

电话:021-64437130

邮箱:hhchen@shmu.edu.cn