科学研究

邵春林博士，复旦大学放射医学研究所党总支书记，二级研究员，博士研究生导师，国家重点研发计划项目首席科学家。先后在日本京都大学、日本国立放射医学综合研究所、英国牛津大学Gray肿瘤研究所等国外著名机构从事科研工作，致力于放射生物学、辐射信号通路与传递等方面的研究，取得了一系列创新性成果，发表论文210余篇，其中SCI论文120余篇，已培养毕业博士、硕士毕业生35名，其中多人获得上海市优秀毕业生称号；先后获得上海市科技进步一等奖与二等奖、上海市优秀发明金奖、中华预防医学会科学技术奖三等奖、上海医学科技奖二等奖、中国科学院自然科学奖二等奖等奖项。主持科技部重点研发计划、国家自然科学基金重点项目等省部级以上科研项目20多项，获教育部新世纪优秀人才、上海市浦江人才、上海公共卫生优秀学科带头人等人才项目支持。兼任中国生物物理学会辐射与环境生物物理专委会会长、COSPAR副理事、中国核学会辐射研究与辐射工艺学会副理事长、上海市核学会副理事长，以及多个专业学会的常委，是科技部重点研发计划重点专项、国家食品药品监督管理总局医疗器械技术审评中心的咨询专家；担任甘肃省重离子医学重点实验室学术委员会主任、多个国家实验室和国家重点实验室的学术委员会委员，Radiat.Med. Prot.副主编、British Journal of Radiology、Journal of Radiation Research等多个国内外学术期刊的编辑。


目前主要研究方向：

1）多束线肿瘤放射免疫研究。主要研究光子、质子、重离子等多种射线对肿瘤细胞的辐射损伤与辐射敏感性，研究肿瘤辐射耐受的分子机制及免疫微环境在其中的作用。

2）辐射旁效应与远端效应研究。在细胞和动物水平上研究电离辐射非靶效应的分子信号通路与应答机制，研究免疫活化在其中的作用。


科技服务：

辐射生物剂量评估：开展放射性从业人员辐射生物剂量的检测与评估等科技服务工作。

发表论文：

  1. Qianping Chen#, Wang Zheng#, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. LACTB2 Renders Radioresistance by Activating PINK1/Parkin-dependent Mitophagy in Nasopharyngeal Carcinoma Cells. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.07.019 (IF 8.7)

  2. Xiaofei Chu#, Wang Zheng#, Qianping Chen, Chen Wang, Saijun Fan*, Chunlin Shao*. HBXIP contributes to radioresistance through NF-κB-mediated expression of XIAP in breast cancer. Radiation Medicine and Protection 2: 39–47, 2021.

  3. Wang Zheng#, Qianping Chen#, Hongxia Liu, Songling Hu, Yuchuan Zhou, Yang Bai, Jianghong Zhang, Yan Pan and Chunlin Shao*. CD81 enhances radioresistance of glioblastoma by promoting nuclear translocation of Rad51. Cancers, 13:1998, 2021. (IF 6.64)

  4. Jianghong Zhang, Yuhong Zhang, Fang Mo, Gaurang Patel, Karl T Butterworth, Chunlin Shao*, Kevin Prise*. Manuscript title: The roles of HIF-1α in radiosensitivity and radiation induced bystander effects under hypoxia. Frontiers in Cell and Developmental Biology, 9: 637454, 2021. (IF 6.68)

  5. Songling Hu#, Lin Zhu#, Yimeng Song#, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang*, Chunlin Shao*. Radiation-induced abscopal reproductive effect is driven by Rac1 nuclear translocation in Sertoli cells. Theranostics. 11(12): 5742-5758, 2021. (IF 11.56)

  6. Lin Zhu#, Songling Hu#, Qian-Ping Chen, Jia-Mei Fu, Hao-Wen Zhang, Jun-Ling Zhang, Yan Pan, Yang Bai, Chun-Lin Shao*. Roles of macrophage in radiation-induced abscopal effect via TNF-α in breast cancer. Int. J. Biol. Sci., 2021; 17(4):926-941. (IF 6.58)

  7. Hongxia Liu, Wang Zheng, Qianping Chen, Yuchuan Zhou, Yan Pan, Jianghong Zhang, Yang Bai and Chunlin Shao*. LncRNA CASC19 Contributes to Radioresistance of Nasopharyngeal Carcinoma by Promoting Autophagy via AMPK-mTOR Pathway. Int. J. Mol. Sci. 22(3), 1407, 2021. (IF 5.92)

  8. Yuchuan Zhou, Chunlin Shao*. Histone methylation can either promote or reduce cellular radiosensitivity by regulating DNA repair pathways. Mut. Res. Review. 787: 108362, 2021. (IF 5.66)

  9. Han Pan, Yimeng Song, Hang Zhang, Yang Bai, Teruaki Konishi, Alisa Kobayashi, Yan Pan*, Chunlin Shao*. Radiation engenders conversed migration and invasion in colorectal cancer cells through opposite modulation of ANXA2/ AKT /GSK3β pathway. American Journal of Cancer Research, 11(1):61-78, 2021. (IF 6.17)

  10. Xinrui Zhao, Chunlin Shao*. Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade. Cancers, 12, 2762, 2020. (IF 6.64)

  11. Xiaofei Chu, Wang Zheng, Juan Wang, Jianghong Zhang, Yan Pan and Chunlin Shao. CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation. Biochemical and Biophysical Research Communications. 531: 328-334, 2020.

  12. Fei Chen#, Yushuo Zhang#, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang*, Chunlin Shao*. Induction of TIGAR accelerates reserve intestinal stem cell division and mitigates lethal gastrointestinal syndrome induced by radiation. Cell Death and Disease. 11: 501, 2020. (IF 8.47)  

  13. Lin Zhu, Qianping Chen, Longshan Zhang, Songling Hu, Wang Zheng, Chen Wang, Yang Bai, Yan Pan, Teruaki Konishi, Jian Guan, Chunlin Shao. CLIC4 regulates radioresistance of nasopharyngeal carcinoma by iNOS after γ-rays but not carbon ions irradiation. American Journal of Cancer Research, 10(5): 1400–1415, 2020. (IF 6.17)

  14. Songling Hu, Chunlin Shao. Progresses of radiation induced bystander and abscopal effects in normal tissues. Radiation Medicine and Protection. 1: 69-74, 2020.

  15. Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. Exosomes from irradiated lung cancer cells carrying ALDOA and ALDH3A1 enhance migration and invasion of recipients by accelerating glycolysis. Molecular and Cellular Biochemistry, 469:77–87, 2020.  

  16. Fang Mo, Yanwu Xu, Junling Zhang, Lin Zhu, Chen Wang, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao*, Jianghong Zhang*. Effects of hypoxia and radiation-induced exosomes on migration of lung cancer cells and angiogenesis of umbilical vein endothelial cells. Radiat. Res., 194, 71–80, 2020.

  17. Wang Zheng#, Qianping Chen#, Chen Wang, Xiaofei Chu, Dan Yao, Lin Zhu, Yan Pan, Jianghong Zhang, Yang Bai, Chunlin Shao*. Inhibition of Cathepsin D (CTSD) enhances radiosensitivity in glioblastoma cells through attenuated autophagy. Molecular Carcinogenesis, 59:651–660. 2020.  

  18. Qianping Chen#, Wang Zheng#, Lin Zhu, Dan Yao, JunLing Zhang ,Chen Wang, Fang Mo,Yimeng Song, hongxia Liu, Songling Hu, Xiaofei Chu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao*. ANXA6 contributes to radioresistance by regulating cell autophagy and migration in nasopharyngeal carcinoma. Frontiers in Cell and Developmental Biology, 8:232, 2020. (IF 6.68)

  19. Jiamei Fu, Lin Zhu, Wenzhi Tu, Xiangdong Wang, Yan Pan, Yang Bai, Bingrong Dang, Jieyi Chen, Chunlin Shao*. Macrophage-mediated secondary bystander effects after different radiations through a p53-dependent pathway. Radiation Research, 193:119-129, 2020。

  20. Chen Dong#, Wenzhi Tu#, Mingyuan He, Jiamei Fu, Alisa Kobayashi, Yoshiya Furusawa, Teruaki Konishi*, Chunlin Shao*. Role of endoplasmic reticulum and mitochondrion in proton microbeam-irradiation induced bystander effect. Radiation Research, 193: 63-72, 2019.

  21. Yang Z, Gu Q, Wang Y, Liu B, Zhou G, Shao C, Ruan J, Jia R, Ge S. Heavy-Ion Carbon Radiation Regulates Long Non-Coding RNAs in Cervical Cancer HeLa Cells. J Cancer. 10 (21): 5022-5030, 2019.

  22. Yi Miao, Yi-Xin Zou, Dan-Ling Gu, Hong-Cheng Zhu, Hua-Yuan Zhu, Li Wang, Jin-Hua Liang, Yi Xia, Jia-Zhu Wu, Chun-Lin Shao, Lei Fan, Zhen Zhang, Wei Xu, Jian-Yong Li. SF3B1 mutation predicts unfavorable treatment-free survival in Chinese chronic lymphocytic leukemia patients. Annals of Translational Medicine. 7(8):176-184, 2019.

  23. Fei Guo, Dexiao Yuan, Junling Zhang, Hang Zhang, Chen Wang, Lin Zhu, Jianghong Zhang, Yan Pan* and Chunlin Shao*. Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State. Frontiers in Cell and Developmental Biology, 2019 Oct 15; 7: 238. (IF 5.2)

  24. Junling Zhang, Dan Yao, Yimeng Song, Yan Pan, Lin Zhu, Yang Bai, Yanwu Xu, Jianghong Zhang*, Chunlin Shao*. Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility. Scientific Reports, (2019) 9:15221.  

  25. Li Xiang; Zhang Wei; Wang Xiaowa; Chen Xue; Pan Hailun; Ruan Yue; Khaledi Navid; Wei Tianhao; He Xiaodong; Zhuo Weihai; Shao Chunlin; Pan Yan; Shi Liqun; Fu Shen; Wang Xufei. Charged particle radiobiology beamline using tandem accelerator-based MeV protons and carbon ions: A pilot study on the track-end radiation quality, variable biological effectiveness and Bayesian beam dosimetry. Physics in Medicine and Biology, 64(16):165004, 2019.

  26. Junling Zhang, Dan Yao, Jianghong Zhang, Yimeng Song, Fang Mo, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao. TGF-β mediates thoracic radiation-induced abscopal effects of testis injury in rat. Biochemical and Biophysical Research Communications. 514(3): 678-683, 2019.

  27. Xiangdong Wang, Wenzhi Tu, Chen Dong, Jiamei Fu, Juan Wang, Chunlin Shao*, Jianghong Zhang*. Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells. Int. J. Radiat. Biol. 95(8): 1051-1057, 2019.

  28. Chen Wang, Wang Zheng, Dan Yao, Qianping Chen, Lin Zhu, Junling Zhang, Yan Pan, Jianghong Zhang, Chunlin Shao*. Upregulation of DNA metabolism-related genes contributes to radioresistance of glioblastoma. Human Gene Therapy Clinical Development. 30(2): 74-87, 2019.

  29. Wenzhi Tu, Chen Dong, Jiamei Fu, Yan Pan, Alisa Kobayashi, Yoshiya Furusawa, Teruaki Konishi and Chunlin Shao*. Both irradiated and bystander effects link with DNA repair capacity and the linear energy transfer. Life Sciences, 222: 228-234, 2019.

  30. Hang Zhang, Yimeng Song, Cuiping Zhou, Yang Bai, Dexiao Yuan, Yan Pan*, Chunlin Shao*. Blocking endogenous H2S signaling attenuated radiation-induced long-term metastasis of residual HepG2 cells through inhibition of EMT. Radiat. Res. 190(4): 374-384, 2018.

  31. Chen X, Wang P, Guo F, Wang X, Wang J, Xu J, Yuan D, Zhang J, Shao C. Autophagy enhanced the radioresistance of non-small cell lung cancer by regulating ROS level under hypoxia condition. Int. J. Radiat. Biol. 93(8): 764-770, 2017.

  32. Wang P, Yuan D, Guo F, Chen X, Zhu L, Zhang H, Wang C, Shao C. Chromatin remodeling modulates radiosensitivity of the daughter cells derived from cell population exposed to low- and high-LET irradiation. Oncotarget. 2017 Apr 20; 8(32): 52823-52836.

  33. Yuexia Xie, Shuang Ye, Jianghong Zhang, Mingyuan He, Dexiao Yuan, Chunlin Shao. Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells. Scientific Reports, 6:38832, 2016.

  34. Yuan D, Xu J, Wang J, Pan Y, Fu J, Bai Y, Zhang J, Shao C. Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5. Oncotarget. 7(22): 32707-22, 2016.  

  35. Jiamei Fu, Juan Wang, Xiangdong Wang, Ping Wang, Jinping Xu, Cuiping Zhou, Yang Bai,Chunlin Shao∗. Signaling factors and pathways of α-particle irradiation induced bilateral bystander responses between Beas-2B and U937 cells. Mutation Research-- Fundamental and Molecular Mechanisms of Mutagenesis. 789: 1-8. 2016.  

  36. Juan Wang, Jinping Xu, Jiamei Fu, Dexiao Yuan, Fei Guo, Cuiping Zhou and Chunlin Shao.MiR-29a Regulates Radiosensitivity in Human Intestinal Cells by Targeting PTEN Gene. Radiat. Res. 186, 292–301, 2016.

  37. Pan, Y., Zhou, C., Yuan, D., Zhang, J. and Shao C. Radiation Promotes Hepatocarcinoma Cell Invasiveness through Epithelial Mesenchymal Transition Mediated by H2S/CSE Pathway. Radiat. Res. 185: 96–105, 2016.  

  38. Jiamei Fu, Dexiao Yuan, Linlin Xiao, Wenzhi Tu, Chen Dong, Weili Liu, Chunlin Shao. The crosstalk between α-irradiated Beas-2B cells and its bystander U937 cells through MAPK and NF-κB signaling pathways. Mutation Research-- Fundamental and Molecular Mechanisms of Mutagenesis. 783:1-8. 2016.

  39. Wenzhi Tu, Chen Dong, Teruaki Konishi, Alisa Kobayashi, Yoshiya Furusawa, Yukio Uchihori, Yuexia Xie, Bingrong Dang, Wenjian Li and Chunlin Shao. G2-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation. Mutation Research -- Genetic Toxicology and Environmental Mutagenesis. 795: 1–6, 2016.

  40. Jihua Nie#, Zhihai Chen, Chunlin Shao, Weiwei Pei, Jie Zhang, Shuyu Zhang, Yang Jiao, Jian Tong*. Analysis of the miRNA–mRNA networks in malignant transformation BEAS-2B cells induced by alpha-particles. Journal of Toxicology and Environmental Health Part A, 2016, 79: 427–435.

  41. Chen Dong, Mingyuan He, Wenzhi Tu, Teruaki Konishi, Weili Liu, Yuexia Xie, Bingrong Dang, Wenjian Li, Yukio Uchihori, Tom K. Hei, Chunlin Shao. The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation. Cancer Letters, 363: 92-100, 2015. (IF 5.99)

  42. Chen Dong, Mingyuan He, Ruiping Ren, Yuexia Xie, Dexiao Yuan, Bingrong Dang, Wenjian Li, Chunlin Shao. Role of MAPK pathway in the bystander effect on lymphocytes co-cultured with macrophages irradiated with -rays and carbon ions. Life Sci. 127: 19-25, 2015.

  43. Xiangdong Wang, Jianghong Zhang*, Jiamei Fu, Juan Wang, Shuang Ye, Weili Liu, Chunlin Shao*. Role of ROS-mediated autophagy in radiation-induced bystander effect of hepatoma cells. Int. J. Radiat. Biol., 91(5): 452–458, 2015.  

  44. Yuexia Xie, Wenzhi Tu, Jianghong Zhang, Mingyuan He, Shuang Ye, Chen Dong, Chunlin Shao. SirT1 knockdown potentiates radiation-induced bystander effect through promotion of c-Myc activity that facilitates ROS accumulation. Mutation Research-- Fundamental and Molecular Mechanisms of Mutagenesis. 772: 23-29, 2015.

  45. Shuang Ye, Dexiao Yuan, Yuexia Xie, Yan Pan, Chunlin Shao. Role of DNA methylation in the adaptive responses induced in a human B lymphoblast cell line by long-term low-dose exposures to γ-rays and cadmium. Mutation Research -- Genetic Toxicology and Environmental Mutagenesis.  773: 34–38, 2014.  

  46. Linlin Xiao, Weili Liu, Jitao Li, Yuexia Xie, Mingyuan He, Jiamei Fu, Wensen Jin and Chunlin Shao. Irradiated U937 Cells Trigger Inflammatory Bystander responses in Human Umbilical Vein Endothelial Cells through the p38 Pathway. Radiat. Res. 182, 111-121, 2014.

  47. Weili Liu, Linlin Xiao, Chen Dong, Mingyuan He, Yan Pan, Yuexia Xie, Wenzhi Tu, Jiamei Fu, Chunlin Shao. Long-term low-dose a-particle enhanced the potential of malignant transformation in human bronchial epithelial cells through MAPK/Akt pathway. Biochemical and Biophysical Research Communications. 447(3): 388-393, 2014.  

  48. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao. Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the malignant proliferation of hepatoma cells.  Mutat. Res.--Fundamental and Molecular Mechanisms of Mutagenesis. 763-764: 10-18, 2014.

  49. Mingyuan He, Yuexia Xie, Chen Dong, Jitao Li, Dexiao Yuan, Yang Bai, Chunlin Shao. Reciprocal bystander effect between α-irradiated macrophage and vicinal hepatocyte is mediated by cAMP communication through a membrane signaling pathway. Mutat Res. 763-764: 1-9, 2014.

  50. Minyuan He, Chen Dong, Teruaki Konishi, Wenzhi Tu, Weili Liu, Naoko Shiomi, Alisa Kobayashi, Yukio Uchihori, Yoshiya Furusawa, Tom K Hei, Bingrong Dang, Chunlin Shao. Differential effects of p53 on bystander phenotypes induced by gamma-ray and high LET heavy ion radiation. Life Sciences in Space Research. 1: 53-59, 2014.

  51. Dang B, Yang Y, Zhang E, Li W, Mi X, Meng Y, Yan S, Wang Z, Wei W, Shao C, Xing R, Lin C. Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts. Life Sci. 97(2):123-128, 2014.  

  52. Bo Shen, Pei-Jie He, Chun-Lin Shao. Norcantharidin induced DU145 cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion. PLos One, 2013; 8(12):e84610.  

  53. Shuang Ye, Dexiao Yuan, Yuexia Xie, Yan Pan, Chunlin Shao. Role of DNA methylation in long-term low-dose γ-radiation induced adaptive response in human B lymphoblast cells. Int. J. Radiat. Biol., 89(11): 898-906, 2013.

  54. Li Jitao, He Mingyuan, Shen Bo, Yuan Dexiao, Shao Chunlin. Alpha particle-induced bystander effect is mediated by ROS via a p53-dependent SCO2 pathway in hepatoma cells. Int. J. Radiat. Biol. 89(12): 1028-1034, 2013.

  55. Yizhong Bao, Dan Wang, Zhiming Li, Yuxing Hu, Aihong Xu, Quanrui Wang, Chunlin Shao, Honghong Chen. Efficacy of a novel chelator BPCBG for removing uranium and protecting against uranium-induced renal cell damage in rats and HK-2 cells. Toxicology and Applied Pharmacology. 269: 17-24, 2013.

  56. Mingyuan He, Ruiping Ren, Dexiao Yuan, Yuexia Xie, Yan Pan, Chen Dong and Chunlin Shao. Radiation Enhances the Invasiveness of Irradiated and Nonirradiated Bystander Hepatoma Cells Through a VEGF-MMP2 Pathway Initiated by p53. Radiat. Res. 180(4): 389-97, 2013.

  57. Dexiao Yuan, Shuang Ye, Yan Pan, Yizhong Bao, Honghong Chen, Chunlin Shao. Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation. Mutat. Res.--Fundamental and Molecular Mechanisms of Mutagenesis. 2013; 757(2):125-31.

  58. Ruiping Ren, Mingyuan He, Chen Dong, Yuexia Xie, Shuang Ye, Dexiao Yuan, Chunlin Shao. Dose response of micronuclei induced by combination radiation of a-particles and r-rays in human lymphoblast cells. Mutat. Res.--Fundamental and Molecular Mechanisms of Mutagenesis. 741-742: 51-56. 2013.

  59. Yu W#, Gu K#, Yu Z, Yuan D, He M, Ma N, Lai S, Zhao J, Ren Z, Zhang X, Shao C, Jiang GL*. Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo. Cancer Lett. 329(1): 109-17, 2013.

  60. Yan Pan, Shuang Ye, Dexiao Yuan, Jianghong Zhang, Yang Bai, Chunlin Shao. Radioprotective role of H2S/CSE pathway in Chang liver cells. Mutat. Res.--Fundamental and Molecular Mechanisms of Mutagenesis. 738-739: 12-18, 2012.  

  61. Zhang J, Xie Y, Xu Y, Shao C. Suppression of Endogenous Hydrogen Sulfide Contributes to the Radiation-Induced Bystander Effects on Hypoxic HepG2 Cells. Radiat. Res. 178: 395–402, 2012.  

  62. Kai Lei, Xiaoqiang Zhu, Rener Xu, Chunlin Shao, Tian Xu, Yuan Zhuang, Min Han. Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response. Current Biology. 22(17):1609-15, 2012.

  63. Yuexia Xie, Jianghong Zhang, Mingyuan He, Ruiping Ren, Shuang Ye, Dexiao Yuan, Chunlin Shao. SirT1 regulates radiosensitivity of hepatoma cells differently under normoxia and hypoxia conditions. Cancer Sci. 103(7): 1238-1244, 2012.

  64. Mingyuan He, Shuang Ye, Ruiping Ren, Chen Dong, Yuexia Xie, Dexiao Yuan, Chunlin Shao. Cytochrome-c mediated a bystander response dependent on inducible nitric oxide synthase in irradiated hepatoma cells. Brit. J. Cancer. 106(5):889-95, 2012.

  65. Yuexia Xie, Jianghong Zhang, Yanwu Xu, Chunlin Shao. SirT1 confers hypoxia-induced radioprotection via the modulation of c-Myc stabilization on hepatoma cells. J. Radiat. Res., 53(1): 44-50, 2012.  

  66. Chen H, Bao Y, Yu L, Jia R, Cheng W, Shao C. Comparison of cellular damage response to low-dose-rate (125)I seed irradiation and high-dose-rate gamma irradiation in human lung cancer cells. Brachytherapy. 11(2): 149-156, 2012.

  67. Bao Y, Chen H, Hu Y, Bai Y, Zhou M, Xu A, Shao C. Combination effects of chronic cadmium exposure and gamma-irradiation on the genotoxicity and cytotoxicity of peripheral blood lymphocytes and bone marrow cells in rats. Mutat Res.--Fundamental and Molecular Mechanisms of Mutagenesis. 743(1-2):67-74, 2012.  

  68. Chen X, Zhu G, Jin T, Shao C, Gu S, Tan M, Zhang Y, Xiao H, Hu H, Yu Y. Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats. Arch Environ Contam Toxicol. 62(1):165-75, 2012.

  69. Qiu J, Zhu G, Chen X, Shao C, Gu S. Combined effects of γ-irradiation and cadmium exposures on osteoblasts in vitro. Environ Toxicol Pharmacol. 33(2): 149-157, 2011

  70. Chen X, Zhu G, Shao C, Jin T, Tan M, Gu S, Zhang Y, Xiao H. Effects of cadmium on bone microstructure and serum tartrate-resistant acid phosphatase 5b in male rats. Exp. Biol. Med. (Maywood). 236(11):1298-305, 2011.  

  71. Jianghong Zhang, Yuexia Xie, Yanwu Xu, Yan Pan, Chunlin Shao. Hydrogen Sulfide Contributes to Hypoxia-Induced Radioresistance on Hepatoma cells. J. Radiat. Res., 52(5):622-628. 2011.  

  72. XF Wang,  JQ Li, JZ Wang, JX Zhang, A Liu, ZJ He, W Zhang, B Zhang, CL Shao, LQ Shi. Current progress of the biological single-ion microbeam at FUDAN. Radiat. Environ. Biophys. 50(3):353-64, 2011.

  73. Yan Pan, Dexiao Yuan, Jianghong Zhang, Chunlin Shao. Cadmium induced radioadaptive response via ATM-independent H2S/cystathionine γ-lyase modulation. Mutat Res., -- Fundamental and Molecular Mechanisms of Mutagenesis. 707(1-2): 67-73, 2011.  

  74. Mingyuan He, Meijia Zhao, Bo Shen, Kevin M Prise, Chunlin Shao*. Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cells. Oncogene, 30: 1947–1955, 2011. (IF 7.2)

  75. Honghong Chen, Lei Yu, Rongfei Jia, Wenying Cheng, Chunlin Shao. The role of nucleophosmin/B23 in radiation-induced chromosomal instability in human lymphoblastoid cells of different p53 genotypes. Int.J. Radiat. Biol. 86(12):1031-43, 2010.

  76. Dexiao Yuan, Yan Pan, Jianghong Zhang, Chunlin Shao. Role of nuclear factor-κB and P53 in radioadaptive response in Chang live cells. Mutation Research-- Fundamental and Molecular Mechanisms of Mutagenesis, 688: 66-71, 2010.  

  77. Chunlin Shao, Jianghong Zhang, Kevin M. Prise. Differential modulation of a radiation induced bystander effect in glioblastoma cells by pifithrin-a and wortmannin. Nucl. Instru. Methods in Phys. Res. B. 268: 627–631, 2010.  

  78. Yan Pan, Dexiao Yuan, Junxiang Zhang, Ping Xu, Honghong Chen, Chunlin Shao. Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity. Radiat. Res. 171(4): 446-453, 2009.  

  79. Kevin M. PRISE, Giuseppe SCHETTINO, Boris VOJNOVIC, Oleg BELYAKOV and Chunlin SHAO. Microbeam Studies of the Bystander Response. J. Radiat. Res., 50: Suppl., A1-A6, 2009.

  80. Xiao Chen, Guoying Zhua, Shuzhu Gu, Taiyi Jin, Chunlin Shao. Effects of cadmium on osteoblasts and osteoclasts in vitro. Environmental Toxicology and Pharmacology 28: 232-236, 2009.

  81. HH Chen, RF Jia, L Yu, MJ Zhao, CL Shao, WY Cheng. Bystander effects induced by continuous low-dose-rate 125I seeds potentiate the killing action of irradiation on human lung cancer cells in vitro. Int. Journal of Radiation Oncology, Biology, Physics, 72(5): 1560-1566, 2008.

  82. Chunlin Shao, Melvyn Folkard, Kathryn D. Held, and Kevin M. Prise. Estrogen enhanced cell-cell signalling in breast cancer cells exposed to targeted irradiation. BMC Cancer, 8:184, 2008.

  83. Chunlin Shao, Melvyn Folkard and Kevin M. Prise. Role of TGF-b1 and nitric oxide in bystander response on targeted glioma cells. Oncogene, 27(4): 434-440, 2008. (IF 7.2)

  84. Chunlin Shao, Kevin M. Prise, Melvyn Folkard. Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts. Mutation Research-- Fundamental and Molecular Mechanisms of Mutagenesis. 638 (1-2): 139-145, 2008.

  85. Chunlin Shao, Yoshiya Furusawa, Yoshitaka Motsumoto, Yan Pan, Ping Xu, Honghong Chen. Effect of Gap Junctional Intercellular Communication on Radiation Responses in Human Neoplastic Cells. Radiat. Res. 167(3): 283-288, 2007.  

  86. Kevin M. Prise, Susanne Burdak-Rothkamm, Melvyn Folkard, Genro Kashino, Chunlin Shao, Laurence Tartier. New insights on radiation-induced bystander signalling and its relationship to DNA repair. International Congress Series 1299: 121-127, 2007.

  87. Kevin M. Prise, Melvyn Folkard, Virginija Kuosaite, Laurence Tartier, Nikolai Zyuzikov, Chunlin Shao. What role for DNA damage and repair in the bystander response? Mutat. Res. -- Fundamental and Molecular Mechanisms of Mutagenesis, 597(1-2):1-4. 2006.  

  88. Chunlin Shao, Yoshiya Furusawa, Yasuhiko Kobayashi, Tomoo Funayama Involvement of gap junctional intercellular communication in the bystander effect induced by broad-beam or microbeam heavy ions. Nucl. Instru. Methods in Phys. Res. B251, 177-182, 2006.

  89. Chunlin Shao, Fiona M. Lyng, Melvyn Folkard, Barry D. Michael and Kevin M. Prise. Calcium Fluxes Modulate Targeted Radiation Induced Bystander Responses in Glioma and Fibroblast Cells. Radiat. Res. 166: 479-487, 2006.

  90. Folkard, M. Prise, K.M.; Shao, C.; Gilchrist, S.; Schettino, G.; Michette, A.G.; Vojnovic, B. Understanding radiation damage to cells using microbeams. Acta Physica Polonica A, 109(3): 257-264, 2006.

  91. Lyng FM, Maguire P, Kilmurray N, Seymour C,  Mothersill C,  Shao C, Folkard  M  and  Prise KM. Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells. Int. J. Radiat. Biol. 82, 393-399, 2006.

  92. Melvyn Folkard, Kevin Prise, Giuseppe Schettino, Chunlin Shao, Stuart Gilchrist, Boris Vojnovic. New insights into the cellular response to radiation using microbeams. Nucl. Instru. Methods in Phys. Res. B, 231, 189-194, 2005.

  93. Chunlin Shao, Melvyn Folkard, Barry D. Michael, Kevin M. Prise. Bystander signalling between glioma cells and fibroblasts targeted with counted particles. Int. J. Cancer, 116, 45-51, 2005.  

  94. Yasuhiko Kobayashi, Tomoo Funayama, Seiichi Wada, Yoshiya Furusawa, Mizuho Aoki, Chunlin Shao, Yuichiro Yokota, Tetsuya Sakashita, Yoshitaka Matsumoto, Takehiko Kakizaki, and Nobuyuki Hamada  Microbeams of heavy charged particles. Biol. Sci. Space, 18(4), 235-240, 2004.

  95. Chunlin Shao, Melvyn Folkard, Barry D. Michael, and Kevin M. Prise. Targeted cytoplasmic irradiation induces bystander responses. Proc. Natl. Acad. Sci. USA 101, 13495-13500, 2004. (IF 10.6)

  96. C Shao, VC Stewart, M Folkard, BD Michael, KM Prise. Radiation-induced bystander signalling in targeted glioma cells. Brit. J. Cancer, 91, S19, 2004.

  97. C Shao, KD Held, M Folkard, BD Michael, KM Prise. Oestrogen modulation of a radiation-induced bystander effect in targeted breast cells. Brit. J. Cancer, 91, S47, 2004.

  98. Chunlin Shao, Yoshiya Furusawa, Mizhuo Aoki. Bystander Effect in Lymphoma Cells Vicinal to Irradiated Neoplastic Epithelial Cells: Nitric Oxide is involved. J. Radiat. Res, 45(1), 97-103, 2004.

  99. C. Shao, K.M. Prise, V. Stewart, M. Folkard and B. D. Michael. Involvement of Nitric Oxide in the Bystander Responses Induced by Microbeam Targeted Cells. Radiat Res. 161, 116-117, 2004

  100. K. M. Prise, G. Schettino, C. Shao, V. Stewart, L. Wu, N. Zyuzikov, M. Folkard and B. D. Michael. Studies of Bystander Responses with the GCI Microbeams. Radiat Res. 161, 118-119, 2004

  101. Chunlin Shao, V. Stewart, M. Folkard, B. D. Michael, and K. M. Prise. Nitric oxide-mediated signalling in the bystander response of individually targeted glioma cells. Cancer Res., 163, 8437-8442, 2003. (IF 8.65)

  102. Chunlin Shao, Yoshiya Furusawa, Yasuhiko Kobayashi, Tomoo Fnnayama and Seiichi Wada. Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. Faseb J., 17, 1422-1427, 2003. (IF 7.2)

  103. Chunlin Shao, Yoshiya Furusawa, Mizhuo Aoki and Koichi Ando. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat. Res., 160, 318-323, 2003.

  104. Chunlin Shao, Mizuho Aoki, and Yoshiya Furusawa. Bystander effect on cell growth stimulation in neoplastic HSGc cells induced by heavy-ion irradiation. Radiat. Environ. Biophys., 42(3), 183-187, 2003.  

  105. Chunlin Shao, Mizhuo Aoki, Yoshiya Furusawa. Nitric Oxide-Induced Revisable Proliferation Inhibition and Cycle Arrests Associated with a Micronucleus Induction in HSG Cells. Nitric Oxide, 8, 83 – 88, 2003.

  106. Chunlin Shao, Yoshiya Furusawa, Mizhuo Aoki, Hideki Matsumoto, Koichi Ando. Nitric oxide-mediated bystander effect induced by heavy-ion radiation in human salivary gland neoplastic cells. Int. J. Radait. Biol. 78, 837-844, 2002.

  107. Huai-Bin Shi, Chun-lin Shao, Zeng-liang Yu. Studies on the mechanisms of the reactions between ethanol and D2O by arc-discharge. Nucl. Instru. Methods in Phys. Res. B, 194, 141-150, 2002.

  108. Huai-Bin Shi, Chun-lin Shao, Zeng-liang Yu. The preliminary study on the chemical synthesis between graphite and water by glow-discharge experiments. Radiat. Phys. Chem., 64, 289-292, 2002.

  109. Shi Huaibin, Shao Chunlin, Yu Zengliang. Synthesis of Amino Acids by Low Energy N+ Implanting into Carboxylic Acid Solutions. Chemistry Online, 1, 02019, 2002.

  110. Chunlin Shao, Mizhuo Aoki, Yoshiya Furusawa. Medium-mediated Bystander Effect on HSG Cells Co-cultured with Cells Irradiated by X-rays or a 290 MeV/u Carbon Beam. J. Radiat. Res., 42, 305-316, 2001.

  111. Chunlin Shao, Mizuho Aoki, Yoshiya Furusawa. Signal Transfer Pathways Involved in the Irradiation-Induced Bystander Effects. J. Radiat. Res., 42, 450, 2001.

  112. Huai-Bin Shi, Chun-Lin Shao and Zeng-Liang Yu, Preliminary study on the way of formation of amino acids on primitive earth under non-reducing conditions. Radiat. Phys. Chem., 62, 393-397, 2001.

  113. Huai-Bin Shi, Chun-Lin Shao and Zeng-Liang Yu. Synthesis of amino acids by arc-discharge experiments, Nucl. Instru. Methods in Phys. Res. B, 183, 369-373, 2001.

  114. Chunlin Shao, Masahiro Saito, Zengliang Yu. Reaction Rate Coefficients of Hydroxyl Radical Inducing DNA Single- and -Type Double- Strand Breaks. Radiat. Environ. Biophys., 39(2), 121-124, 2000.

  115. Xiangqin Wang, Chunlin Shao, Jianming Yao, Zengliang Yu. Mass and Energy Deposition Effects of Implanted Ions on Solid Sodium Formate. Radiat. Phys. Chem., 59, 67-70, 2000.

  116. Zengliang Yu, Jianwei Han, Xiangqin Wang, Weidong Huang and Chunlin Shao. Chemical Synthesis of Biomolecules in the Origin of Life Simulated by Ions Implantation.《The Role of Radiation in the Origin and Evolution of Life》. Edited by Mitsuhiko Akaboshi, Noriko Fujii and Rafael  Navarro-Gonzalez, Kyoto University Press, Kyoto Japan, 2000, pp175-184.  

  117. Chunlin Shao, Masahiro Saito, Zengliang Yu. Formation of Single- and Double-Strand Breaks of pBR322 Plasmid Irradiated in the Presence of Scavengers. Radiat. Environ. Biophys., 38(2), 105-109, 1999.  

  118. Chunlin Shao, Masahiro Saito, Zengliang Yu. Radiation Induced DNA Strand Breaks Measured by a Modified Method of Gel Scanning. Radait. Phys. Chem., 56, 547-551, 1999.

  119. Chunlin Shao, Jianming Yao, Xiangqin Wang, Zengliang Yu. N+ Ions Irradiation-Induced Mass Deposition in Sodium Carboxylic Molecules. Radiat. Phys. Chem., 51(2), 117-120, 1998.

  120. Wang Xiangqin, Han Jianwei, Shao Chunlin, Yu Zengliang. Synthesis of Amino Acids from Sodium Carboxylic Induced by KeV Nitrogen Ions. Viva Origino, 26(2), 109-115, 1998

  121. Chunlin Shao, Zengliang Yu. Dose Effects of a N+ Ion Beam Irradiation-Induced Damage to 5'-AMP and Its Components. Radiat. Phys. Chem., 49(3), 337-345, 1997.  

  122. Chunlin Shao, Zengliang Yu. Phosphate Release from N+ Ions Irradiated 5'-CMP Nucleotide and Its Kinetics. Radiat. Phys. Chem., 50(6), 561-565, 1997.

  123. Chunlin Shao, Zengliang Yu. Mass Deposition in Tyrosine Implanted by N+ Ion Beam. Radiat. Phys. Chem., 50(6), 595-599, 1997.  

  124. Chunlin Shao, Zengliang Yu. Research into Releasing Inorganic Phosphate and Base from 5'-dTMP Irradiated by a Low Energy Ion Beam. Radiat. Phys. Chem., 44(6), 651-654, 1994.  

  125. Chunlin Shao, Zengliang Yu. Dose Effect of the Tyrosine Sample Radiated by a Low Energy N+ Ion Beam. Radiat. Phys. Chem., 43(4), 349-351, 1994.   


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